Progress in bacterial urease complexes and their activation mechanisms.

Author: Xiaojiao LI ¹ ; Shengguo ZHAO ¹ ; Nan ZHENG ¹ ; Jianbo CHENG ² ; Jiaqi WANG ¹
Author Information

1. State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
2. College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, Anhui, China.
Publication Type:Journal Article
Keywords: accessory protein; activation mechanism; bacterial urease; structural protein
MeSH: Bacterial Proteins; Nickel; Urease; metabolism
From: Chinese Journal of Biotechnology 2019;35(2):204-215
CountryChina
Language:Chinese
Abstract: Urease decomposes urea to ammonia, and has application potential in agriculture and medical treatment. Urease proteins include structural proteins (UreA, UreB and UreC) and accessory proteins (UreD/UreH, UreE, UreF and UreG), each of them has its own unique role in urease maturation. The structural proteins form the active center of urease, and the accessory proteins are responsible for the delivery of nickel. We review here the structure and function of bacterial urease complexes, and how each protein interacts to complete the activation process. We hope to provide theoretical basis for the regulation of urease activity and the development of urease inhibitors.