Baeyer-Villiger monooxygenases in the biosynthesis of microbial secondary metabolites.

Author: Yangli LI ¹ ; Xiaoyu YANG ¹ ; Zixin DENG ¹ ; Dongqing ZHU ¹
Author Information

1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, Hubei, China.
Publication Type:Journal Article
Keywords: Baeyer-Villiger oxidation; biocatalysis; biosynthesis; flavin-dependent monooxygenase
MeSH: Biocatalysis; Catalysis; Mixed Function Oxygenases; Oxidation-Reduction; Protein Engineering
From: Chinese Journal of Biotechnology 2019;35(3):351-362
CountryChina
Language:Chinese
Abstract: Baeyer-Villiger monooxygenases, a well-studied class of flavin-dependent enzymes, catalyze the conversion of ketones to lactones or esters and the oxygenation of heteroatoms, which possesses great practical prospect in synthetic chemistry and biocatalysis. In this review, we focus on Baeyer-Villiger oxidations involved in biosynthesis of microbial secondary metabolites and discuss the characteristics of these Baeyer-Villiger oxidations and Baeyer-Villiger monooxygenases, to provide reference for the protein engineering of Baeyer-Villiger monooxygenases.