Correlation of glutamate dehydrogenase with several tumors.

Author: Hai HOU ¹ ; Chao LUO ¹ ; Zhonghao CHEN ¹ ; Xudong DENG ¹ ; Yao SUN ² ; Xiangxi WANG ²
Author Information

1. School of Life Sciences, Key Laboratory for Space Bioscience & Biotechnology, Northwestern Polytechnical University, Xi'an 710072, Shaanxi, China.
2. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
Publication Type:Journal Article
Keywords: breast cancer; colorectal carcinoma; glioma; glutamate dehydrogenase; ovarian cancer; taxonomic
MeSH: Carbon; Glioma; Glutamate Dehydrogenase; Humans; Mitochondria; Nitrogen
From: Chinese Journal of Biotechnology 2019;35(3):389-395
CountryChina
Language:Chinese
Abstract: Most organisms contain glutamate dehydrogenase (E.C. 1.4.1.2-1.4.1.4). In eukaryotes, the enzyme is mainly present in mitochondria. This enzyme plays a vital role in the metabolism of nitrogen and carbon and the signaling pathway. Studies have found that glutamate dehydrogenase has a certain relationship with the occurrence and development of tumors, which is significant for tumor research, but reviews on its relationship with human tumors are rare. This review summarized the relationship between glutamate dehydrogenase and breast cancer, glioma, colorectal cancer and ovarian cancer, etc, thus providing assistance for related research.