Roles of signaling molecules in biofilm formation.

Chuntian TU; Yang Wang; Li YI; Yuxin Wang; Baobao Liu; Shenglong Gong

Return

Roles of signaling molecules in biofilm formation.

Author: Chuntian TU ¹ ; Yang WANG ¹ ; Li YI ² ; Yuxin WANG ¹ ; Baobao LIU ¹ ; Shenglong GONG ¹
Author Information

1. Key Laboratory of Molecular Pathogen and Immunology of Animal of Luoyang, College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471003, Henan, China.
2. College of Life Sciences, Luoyang Normal University, Luoyang 471022, Henan, China.
Publication Type:Journal Article
Keywords: biofilm; c-di-GMP; quorum sensing; sRNA; signaling molecules
MeSH: Bacterial Proteins; Biofilms; Cyclic GMP; Gene Expression Regulation, Bacterial; Protein Binding; Quorum Sensing
From: Chinese Journal of Biotechnology 2019;35(4):558-566
CountryChina
Language:Chinese
Abstract: Bacterial biofilm refers to a tunicate-like biological group composed of polysaccharide, protein and nucleic acid secreted by bacteria on the surface of the mucous membrane or biological material. The biofilm formation is a major cause of chronic infections. Bacteria could produce some secondary metabolites during the growth and reproduction. Some of them act as signaling molecules allowing bacteria to communicate and regulate many important physiological behaviors at multiple-cell level, such as bioluminescence, biofilm formation, motility and lifestyles. Usually, these signal molecules play an important role in the formation of bacterial biofilm. We review here the effects of related signal molecules of Quorum Sensing, cyclic diguanylate, Two-Component Systems and sRNA on the biofilm formation. Focusing on these regulation mechanism of signal molecules in the process of biofilm formation is necessary for the prevention and treatment of some chronic diseases.