Progress in vaccine development based on baculovirus expression vector system.

Rui Rong; Tingting LI; Yuyun Zhang; Ying GU; Ningshao Xia; Shaowei LI

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Progress in vaccine development based on baculovirus expression vector system.

Author: Rui RONG ¹ ; Tingting LI ¹ ; Yuyun ZHANG ² ; Ying GU ¹ ; Ningshao XIA ¹ ; Shaowei LI ¹
Author Information

1. National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Life Sciences, Xiamen University, Xiamen 361102, Fujian, China.
2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian, China.
Publication Type:Journal Article
Keywords: baculovirus; insect cell; protein expression; vaccine; virus-like particles
MeSH: Animals; Baculoviridae; Genetic Vectors; Prospective Studies; Recombinant Proteins; Vaccines
From: Chinese Journal of Biotechnology 2019;35(4):577-588
CountryChina
Language:Chinese
Abstract: Baculovirus expression vector system (BEVS) has been successfully applied to the over-expression of various proteins, thus providing sufficient materials for vaccine research. Compared to other systems, BEVS has many advantages: baculovirus solely being parasitic in invertebrates, the resultant products conferring high safety to mammalian, high expression level of recombinant proteins, preferable folding for eukaryotic protein, proper post-translational modification required for biological function, suitable for multiple genes co-expression and large-scale production with serum-free culture media. To better understand the advantages and prospective of BEVS for the vaccine research, this article will review the development of BEVS and its application on vaccine research.