Progress in epigenetic modification of mRNA and the function of m6A modification.

Haili Gan; Ling Hong; Fenglian Yang; Dingfeng Liu; Liping Jin; Qingliang Zheng

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Progress in epigenetic modification of mRNA and the function of m6A modification.

Author: Haili GAN ¹ ; Ling HONG ¹ ; Fenglian YANG ¹ ; Dingfeng LIU ¹ ; Liping JIN ¹ ; Qingliang ZHENG ¹
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1. Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
Publication Type:Journal Article
Keywords: N1-methyladenosine (m1A); N6-methyladenosine (m6A); cell differentiation; epigenetic modification of mRNA; mRNA metabolism; pseudouridine
MeSH: Adenosine; analogs & derivatives; genetics; metabolism; Cell Differentiation; genetics; Embryonic Development; genetics; Epigenesis, Genetic; Gene Expression Regulation; RNA Processing, Post-Transcriptional; RNA, Messenger; metabolism
From: Chinese Journal of Biotechnology 2019;35(5):775-783
CountryChina
Language:Chinese
Abstract: Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the progress of cells through modulating mRNA metabolism and translation. Other mRNA modifications, including N1-methyladenosine (m¹A), 5-methylcytosine (m⁵C) and pseudouridine, together with m⁶A form the epitranscriptome of mRNA that accurately modulate the mRNA translation. Here we review the types and characteristic of mRNA epigenetic modifications, especially the recent progresses of the function of m⁶A, we also expect the main research direction of m⁶A epigenetic modification in the future.