Progress in the molecular mechanism of KaiA regulating cyanobacterial circadian clock.

Author: Jinkui LI ¹ ; Chunyu CAO ¹ ; Lingling YU ¹ ; Sen LIU ¹
Author Information

1. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical School, China Three Gorges University, Yichang 443002, Hubei, China.
Publication Type:Journal Article
Keywords: circadian clock; clock protein KaiA; core oscillator; cyanobacterium
MeSH: Bacterial Proteins; genetics; metabolism; Circadian Clocks; genetics; Circadian Rhythm Signaling Peptides and Proteins; metabolism; Cyanobacteria; genetics; Enzyme Activation; genetics
From: Chinese Journal of Biotechnology 2019;35(5):795-804
CountryChina
Language:Chinese
Abstract: The cyanobacterial circadian clock has three relatively independent parts: the input path, the core oscillator, and the output path. The core oscillator is composed of three clock proteins: KaiA, KaiB, and KaiC. The interactions among these three proteins generate a rhythmic signal and convey the input signals to the output signals to maintain the accuracy and stability of the oscillation of downstream signals. Based on the cyanobacterial circadian clock and the structure, function, and interaction of the clock proteins of the core oscillator, combining the recent results from our laboratory, this review summarized the recent progresses of the molecular mechanism of KaiA in regulating KaiC's enzymatic activity, mediating phase reset of the oscillator, and competing with CikA for the binding site of KaiB.