Dental stem cell and dental tissue regeneration.
10.1007/s11684-018-0628-x
- Author:
Qiming ZHAI
1
;
Zhiwei DONG
2
;
Wei WANG
3
;
Bei LI
4
;
Yan JIN
5
Author Information
1. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China.
2. Department of Oral and Maxillofacial Surgery, General Hospital of Shenyang Military Area Command, Shenyang, 110840, China.
3. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Stomatology, Department of Operative Dentistry and Endodontics, School of Stomatology, Fourth Military Medical University, Xi'an, 710032, China.
4. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China. lbfmmu@163.com.
5. State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Center for Tissue Engineering, Fourth Military Medical University, Xi'an, 710032, China. yanjin@fmmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
periodontal regeneration;
pulp regeneration;
stem cells
- MeSH:
Adult Stem Cells;
physiology;
Animals;
Cell Differentiation;
Humans;
Stem Cell Transplantation;
Tissue Engineering;
Tooth;
cytology;
growth & development;
physiology;
Wound Healing
- From:
Frontiers of Medicine
2019;13(2):152-159
- CountryChina
- Language:English
-
Abstract:
The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments.
