Mesenchymal stem cells and immune disorders: from basic science to clinical transition.
10.1007/s11684-018-0627-y
- Author:
Shihua WANG
1
;
Rongjia ZHU
1
;
Hongling LI
1
;
Jing LI
1
;
Qin HAN
1
;
Robert Chunhua ZHAO
2
Author Information
1. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China.
2. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, 100005, China. zhaochunhua@ibms.pumc.edu.cn.
- Publication Type:Journal Article
- Keywords:
clinical transition;
immune disorders;
mesenchymal stem cell
- MeSH:
Cell Differentiation;
Humans;
Immune System Diseases;
immunology;
Mesenchymal Stem Cell Transplantation;
Mesenchymal Stem Cells;
immunology;
physiology;
Randomized Controlled Trials as Topic;
Regenerative Medicine
- From:
Frontiers of Medicine
2019;13(2):138-151
- CountryChina
- Language:English
-
Abstract:
As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e., "subtotipotent stem cell" hypothesis, MSC system, and "Yin and Yang" balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database ( http://clinicaltrials.gov ) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application.
