Regulation of T cell immunity by cellular metabolism.
10.1007/s11684-018-0668-2
- Author:
Zhilin HU
1
;
Qiang ZOU
2
;
Bing SU
3
Author Information
1. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
2. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. Qzou1984@sjtu.edu.cn.
3. Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. bingsu@sjtu.edu.cn.
- Publication Type:Journal Article
- Keywords:
T cell immunity;
metabolic checkpoints;
metabolic pathways;
nutrient uptake
- MeSH:
Animals;
Cell Physiological Phenomena;
Humans;
Immunity, Cellular;
physiology;
Metabolic Networks and Pathways;
immunology;
T-Lymphocytes;
immunology;
metabolism
- From:
Frontiers of Medicine
2018;12(4):463-472
- CountryChina
- Language:English
-
Abstract:
T cells are an important adaptive immune response arm that mediates cell-mediated immunity. T cell metabolism plays a central role in T cell activation, proliferation, differentiation, and effector function. Specific metabolic programs are tightly controlled to mediate T cell immune responses, and alterations in T cell metabolism may result in many immunological disorders. In this review, we will summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function.
