Interplay between diet and genetic susceptibility in obesity and related traits.
10.1007/s11684-018-0648-6
- Author:
Tiange WANG
1
;
Min XU
1
;
Yufang BI
1
;
Guang NING
2
Author Information
1. State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
2. State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. gning@sibs.ac.cn.
- Publication Type:Journal Article
- Keywords:
diet;
genetic susceptibility;
interaction;
obesity
- MeSH:
Body Mass Index;
Diet;
Gene-Environment Interaction;
Genetic Predisposition to Disease;
Humans;
Life Style;
Obesity;
epidemiology;
genetics;
Observational Studies as Topic;
Randomized Controlled Trials as Topic
- From:
Frontiers of Medicine
2018;12(6):601-607
- CountryChina
- Language:English
-
Abstract:
The incidence of obesity has been rapidly increasing, and this condition has become a major public health threat. A substantial shift in environmental factors and lifestyle, such as unhealthy diet, is among the major driving forces of the global obesity pandemic. Longitudinal studies and randomized intervention trials have shown that genetic susceptibility to obesity may interact with dietary factors in relation to the body mass index and risk of obesity. This review summarized data from recent longitudinal studies and intervention studies on variations and diets and discussed the challenges and future prospects related to this area and public health implications.
