Immunoregulatory effects of Tripterygium wilfordii Hook F and its extracts in clinical practice.
10.1007/s11684-018-0649-5
- Author:
Dan LUO
1
;
Zhengyun ZUO
2
;
Hongyan ZHAO
3
;
Yong TAN
4
;
Cheng XIAO
5
Author Information
1. Traditional Chinese Medicine Hospital of Changping District, Beijing, 102200, China.
2. Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China.
3. Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100070, China.
4. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100070, China.
5. Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, 100029, China. xc2002812@126.com.
- Publication Type:Journal Article
- Keywords:
Tripterygium wilfordii Hook F;
clinical studies;
immunoregulation
- From:
Frontiers of Medicine
2019;13(5):556-563
- CountryChina
- Language:English
-
Abstract:
Tripterygium wilfordii Hook F (TwHF) and its extracts have long been used for the treatment of rheumatoid arthritis, autoimmune diseases, and kidney disease due to their anti-inflammatory, immunoregulatory, and other pharmacological effects. However, the clinical immunoregulatory effects of TwHF and its extracts remain unclear, so we reviewed their effects for use in clinical practice. This review provides a comprehensive summary of the recent literature on the immunoregulatory effects of TwHF and its extracts in clinical studies. TwHF and its extracts affect the proliferation and activation of Tand B cells; ratio of Tcell subsets; inflammatory response of monocytes, macrophages, and immunoglobulins; and secretion of many cytokines. Together, these effects dictate immune function in a variety of diseases. TwHF and its extracts can be used alone or in combination with existing therapies against many immune disorders through immunomodulation.
