Biomimetic nanoparticles for inflammation targeting.
10.1016/j.apsb.2017.12.002
- Author:
Kai JIN
1
;
Zimiao LUO
1
;
Bo ZHANG
1
;
Zhiqing PANG
1
Author Information
1. School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
Biomimetic nanoparticles;
CAM, cellular adhesion molecule;
CCL5, chemokine (C-C motif) ligand 5;
CD40L, cluster of differentiation 40 ligand;
CTC, circulating tumor cell;
CTL, cytotoxic T cell or CD8+ T cell;
CXCL4, chemokine (C-X-C motif) ligand 4;
CXCR1, chemokine (C-X-C motif) receptor 1;
Cell membrane;
Cell membrane proteins;
Cy7, cyanine 7;
DC, dendritic cell;
DSPE-PEG, distearoyl Phosphoethanolamine-poly(ethylene glycol);
GPIV, glycoprotein IV;
GPIX, glycoprotein IX;
GPIbα, glycoprotein Ibα;
GPV, glycoprotein V;
GPVI, glycoprotein VI;
HUVEC, umbilical cord vascular endothelial cell;
IBD, inflammatory bowel disease;
ICAM-1, intercellular cellular adhesion molecule-1;
IL, interleukin;
IgG, immunoglobulin G;
Immune cells;
Inflammation targeting;
LFA-1, lymphocyte function associated antigen-1;
LLV, leukocyte-like vector;
LPS, lipopolysaccharide;
MHC, major histocompatibility complex;
MRI, magnetic resonance imaging;
Mac-1, macrophage adhesion molecule-1;
Molecular imaging;
NM-NP, neutrophil membrane-coated nanoparticle;
PECAM-1, platelet-endothelial cellular adhesion molecule-1;
PLA-PEG, poly(lactic acid)-poly(ethylene glycol);
PLGA, poly(lactic-co-glycolic acid);
PNP, platelet membrane-cloaked nanoparticle;
PSGL-1, P-selectin glycoprotein ligand-1;
RA, rheumatoid arthritis;
RBC, red blood cell;
SLeX, sialyl lewis X;
SPIO, super paramagnetic iron oxide;
TGF-β, transforming growth factor β;
TNF-α, tumor necrosis factor-α;
Targeting ligands;
Th cell, T-helper cell or CD4+ T cell;
VCAM-1, vascular cellular adhesion molecule-1;
VLA-4, very late antigen-4;
VWF, Von Willebrand factor;
apoE–/– mice, Apolipoprotein e knockout mice
- From:
Acta Pharmaceutica Sinica B
2018;8(1):23-33
- CountryChina
- Language:English
-
Abstract:
There have been many recent exciting developments in biomimetic nanoparticles for biomedical applications. Inflammation, a protective response involving immune cells, blood vessels, and molecular mediators directed against harmful stimuli, is closely associated with many human diseases. As a result, biomimetic nanoparticles mimicking immune cells can help achieve molecular imaging and precise drug delivery to these inflammatory sites. This review is focused on inflammation-targeting biomimetic nanoparticles and will provide an in-depth look at the design of these nanoparticles to maximize their benefits for disease diagnosis and treatment.
