Progress in hepatocyte status detection and its application in bioartificial liver support system.
10.7507/1001-5515.201705066
- Author:
Shichen XU
1
,
2
;
Changzhe WU
3
;
Guanghao ZHANG
3
;
Cheng ZHANG
3
;
Xiaolin HUO
1
,
2
Author Information
1. Beijing Key Laboratory of Biological Electromagnetics, Institute of Electrical Engineering of the Chinese Academy of Sciences, Beijing 100190, P.R.China
2. University of Chinese Academy of Sciences, Beijing 100049, P.R.China.
3. Beijing Key Laboratory of Biological Electromagnetics, Institute of Electrical Engineering of the Chinese Academy of Sciences, Beijing 100190, P.R.China.
- Publication Type:Journal Article
- Keywords:
bioartificial liver support system;
bioreactor;
detection method;
hepatocyte status;
indicator
- From:
Journal of Biomedical Engineering
2018;35(1):151-155
- CountryChina
- Language:Chinese
-
Abstract:
Bioartificial liver support system (BALSS) provides a new way to treat liver failure and leaves more time for patients who are waiting for liver transplantation. It has detoxification function as well as the human liver, at the same time it can provide nutrition and improve the internal environment inside human body. Bioreactors and hepatocytes with good biological activity are the cores of BALSS which determine the treatment effect. However, in the course of prolonged treatment, the function and activity of hepatocytes might be greatly changed which could influence the efficacy. Therefore, it is very important to detect the status of the hepatocytes in BALSS. This paper presents some common indicators of cell activity, detoxification and synthetic functions, and also introduces the commonly detection methods corresponding to each indicator. Finally, we summarize the application of detection methods of the hepatocyte status in BALSS and discuss its development trend.
