An experimental system on heart resistance by split dose hyperthermia
10.3348/jkrs.1983.19.3.475
- Author:
Myung Hee YOO
;
Kyung Ja LEE
;
Chung Sik RHEE
- Publication Type:Original Article
- MeSH:
Animals;
Fever;
Heart;
Hot Temperature;
Mice;
Skin;
Tail
- From:Journal of the Korean Radiological Society
1983;19(3):475-483
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The study was undertaken to evaluate the heat resistance by split dose hyperthermia in various time intervaland temperature. For the experiments, 96 mice were divided into 2 groups: the first, 36 mice were used to evaluatethe skine reaction of mouse tail to single dose hyperathermia, the second, 60 mice were used to evaluate heatresistance by split dose hyperthermia in variuos time intervals. The results obtained are summarized as follows;1. The ND was 101 minutes at 43degrees centigrade(C) and 24 minutes at 45degrees C. 2. For a 1degrees C increasein temperature, a half in time was required to same degree of skin reaction. 3. Heat resistance was significantlydeveloped in split dose hyperthermia at 43degrees C and 45degrees C. 4. Development, maximum and decay of heatresistance were constant regardless of change in temperature. In summary, heat resistance in split dosehyperthermia is important in study and clinical application of heat therapy in malignant disease.
