Comparison of Wound Healing Effect of Different Forms of Chitosan.
- Author:
Byung Ha LEE
1
;
Man Soo SUH
;
Hyung Ho RYU
;
Sae Jung PARK
;
Jung Duck YANG
;
Byung Cha CHO
;
Jung Hwan MOON
;
Ho Yoon JUNG
;
Dong Gul LEE
;
Jae Woo PARK
;
In San KIM
;
Sang Woo KIM
;
Eun Hee BAE
;
Dong Sin LEE
Author Information
1. Department of Plastic & Reconstructive Surgery, Daegu Fatima Hospital, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Chitosan;
Wound healing
- MeSH:
Bandages;
Chitin;
Chitosan*;
Fibroblasts;
Porifera;
Wound Healing*;
Wounds and Injuries*
- From:Journal of the Korean Society of Plastic and Reconstructive Surgeons
2004;31(3):343-350
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study is to compare the effect of wound healing using three different types of chitin, which include the shapes of sponge, velvet, thick non-woven fabrics, and thin non-woven fabrics. The sponge type had more capacity to absorb the first discharge of a wound than the velvet type and the two non-woven fabrics types. Instead of absorbing the discharge effectively, the velvet type showed a difficulty to take off the dressing stuff from a wound since it was solidly stuck to the wound. The sponge type showed less infiltration of inflammatory cells, producing angiogenesis and fibroblast faster than any other types. Next, the thick non-woven fabrics type was a little more effective than the thin non-woven fabrics type: However, there was no difference between two types. The velvet type sustained the infiltration of inflammatory cells for the longest duration, producing slower angiogenesis and fibroblast. In wound contraction and wound healing, the sponge type was most effective with statistical significance than any other types(p<0.05). The two types of non-woven fabrics did not present any statistical significance in wound contraction, wound epithelization and wound healing(p>0.05). In conclusion, the sponge type showed the best effectiveness to absorb the early discharge, facilitating the progress of inflammatory phase to increase the healing rate. It induced an early healing of wound caused by wound contraction rather than by wound epithelization.
