Allopurinol hypersensitivity syndrome and pure red cell aplasia associated with allopurinol treatment.
- Author:
Jin Ho LEE
1
;
Jong Hun HEO
;
Kyung A KWON
;
Dae Hui HAN
;
Jong Woon HWANG
;
Seong CHO
;
Sung Rok KIM
Author Information
1. Department of Internal Medicine, Masan Samsung Hospital Sungkyunkwan University School of Medicine, Masan, Korea. jolinkong@hanmail.net
- Publication Type:Case Report
- Keywords:
Allopurinol;
Pure red-cell aplasia
- MeSH:
Allopurinol;
Eosinophilia;
Fever;
Humans;
Hypersensitivity;
Kidney;
Leukocytosis;
Liver;
Red-Cell Aplasia, Pure;
Renal Insufficiency, Chronic;
Skin;
Uric Acid
- From:Korean Journal of Medicine
2009;76(2):220-224
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allopurinol is widely used to reduce serum uric acid levels and, generally, has mild side effects. Rarely, allopurinol hypersensitivity syndrome occurs and this consists of severe systemic skin lesions, fever, reduced kidney and liver function, and leukocytosis with eosinophilia. Extremely rarely, allopurinol-induced pure red cell aplasia is reported. We report a case of allopurinol hypersensitivity syndrome and pure red cell aplasia following allopurinol therapy for eight weeks and the disease response to steroid therapy in a patient with chronic renal insufficiency.
