A Study of 3 Cases of Synovial Sarcoma by Immunohistochemical Stain and Electron Microscopy
10.4055/jkoa.1996.31.2.381
- Author:
Sang Ho HA
;
Sang Hong LEE
;
Dong Min SHIN
;
Mi Sook LEE
;
Ho Jong JEON
- Publication Type:Original Article
- Keywords:
Synovial sarcoma;
Immunohistochemistry;
Electron microscopy
- MeSH:
Antibodies;
Basement Membrane;
Carcinosarcoma;
Connective Tissue Cells;
Epithelial Cells;
Immunohistochemistry;
Intercellular Junctions;
Keratins;
Microscopy, Electron;
Muramidase;
S100 Proteins;
Sarcoma, Synovial;
Stem Cells;
Synovial Membrane;
Vimentin
- From:The Journal of the Korean Orthopaedic Association
1996;31(2):381-387
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Synovial sarcoma is a distinct and generally recognized soft tissue tumor that it’s origin still raises controversy. The synovial origin of synovial sarcoma has not been determined despite the accepted terminology implying synovium as stem cell. Three cases of primary synovial sarcoma (2 fibrous monophasic, 1 biphasic type) were studied with a panel of antibodies against different types of cytokeratin and other markers (EMA, CEA, vimentin, S-100 protein, lysozyme, 1-antichymotrypsin). Spindle shaped-cell in monophasic synovial sarcoma showed reactivity for CK7 and pancytokeratin. Epithelial cells lining of glands in biphasic synovial sarcoma reactive for CK7, pancytokeratin, EMA, and focally CEA but spindle cells only positive for vimentin. By electron microscopy, fibrous monophasic synovial sarcoma showed pseudogland formation with intercellular junctions of paired subplasmalemmal destiny and discontinuous basal lamina. These results indicate that synovial sarcoma showes epithelial differentiation. We believe that synovial sarcoma arises in pluripotential connective tissue cells that is able to be differentiated into both mesenchymal and epithelial components. So, synovial sarcoma have been considered carcinosarcoma of soft tissues depending on the type of differentiation.
