Biological Effect of TGF
10.4055/jkoa.1995.30.5.1489
- Author:
Kyung Jin SONG
- Publication Type:Original Article
- Keywords:
Intervertebral disc;
Cell culture;
Growth factor;
Biosynthesis;
Repair
- MeSH:
Cell Culture Techniques;
Humans;
Intervertebral Disc;
Proteoglycans;
Transforming Growth Factors
- From:The Journal of the Korean Orthopaedic Association
1995;30(5):1489-1495
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
I have examined the effects of a growth factor, transforming growth factor(TGF)-B 1, on the rates of proteoglycan synthesis, aggregation potenital, and phenotypic expression of proteoglycans from human cervical intervertebral discs maintained in a cell culture system. A cell culture system for transitional and nuclear regions of degenerated human cervical intervertebral disc disc was devised to assess the biosynthetic response, assayed by 35S-sulfate incorporation into proteoglycan and protein synthesis assayed by 35S-methionine incorporation. And I had the data as the TGF-B 1 has an effect on the proteoglycan synthesis in quantitative and qualitative analysis in the cell culture system of the human intervertebral disc. TGF-B 1 may be used as a therapeutic alternative to degenerated disc disease.
