The Inhibitory Effects of 5-fluorouracil on Experimental Proliferative Vitreoretinopathy.
- Author:
Kwang Soo KIM
1
;
Sung Youl PARK
;
Joon Sup OH
Author Information
1. Department of Ophthalmology, Keimyung University School of Medicine, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Fibroblast;
5- Fluorouracil;
Proliferative vitreoretinopathy
- MeSH:
Epiretinal Membrane;
Fibroblasts;
Fluorouracil*;
Intravitreal Injections;
Rabbits;
Retina;
Retinal Detachment;
Retinaldehyde;
Vitrectomy;
Vitreoretinopathy, Proliferative*
- From:Journal of the Korean Ophthalmological Society
1993;34(1):53-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Proliferative vitreoretinopathy (PVR) is the main cause of failure in retinal reattachment surgery, Vitrectomy combined with pharmacologic therapy to inhibit proliferating and contracting epiretinal membranes appears to be a promismg approach in the management of PVR. We investigated the inhibitory effect of intravitreal 5-fluorouracil (5-FU) on experimental PVE induced by intravitreal injection of homologous dermal fibroblast in pigmented rabbits. At 6 weeks after intravitreal injection, Goup I (fibroblast only), Group II (early treatment with 1mg of 5-FU), and Group Ill (delayed treatment with 1mg of 5-FU) developed the retinal detachment in 85.7%, 33.3%, and 58.3% respectively. The rate of retinal detachment was lower in treatment groups than in non-treatment group, but there was a statistically significant difference only between non-treatment group (Group I) and early-treatment group (Group II) (p<0.05). In the group that only 5-FU was injected (Group IV), the retinas were preserved in normal clinically and pathologically. These results show that 5-FU may exert a significant anti proliferative effect on intraocular proliferative disorders including PVR especially if the drug is administered more earlier.
