Renal Transport of Urate.
- Author:
Sik LEE
1
;
Kyung Pyo KANG
;
Sung Kyew KANG
Author Information
1. Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Jeonbuk, Korea. hope@chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Uric acid;
Urate transporters;
Proximal tubule
- MeSH:
Epithelial Cells;
Humans;
Ion Transport;
Uric Acid*
- From:Electrolytes & Blood Pressure
2005;3(2):79-81
- CountryRepublic of Korea
- Language:English
-
Abstract:
All urate transport occurs across the renal epithelial cells of the proximal tubule. Most of the filtered urate is reabsorbed in the S1 segment of the early proximal tubule. This is followed by tubular secretion in the S2 segment of the proximal tubule and approximately 50% of the filtered urate flows back into the tubular lumen. Most of the secreted urate undergoes postsecretory reabsorption that occurs predominantly in the last S3 segment of the proximal tubule. Recently, four proteins that transport urate have been identified at the molecular level. These proteins are an electrogenic urate uniporter, urate transporter/channel (UAT), two members of the organic anion transporter (OAT) family, OAT1 and OAT3, and a protein with some homology to OAT4, designated URAT1.
