A proposal of injection points of botulinum toxin into temporal region for chronic migraine.
10.14368/jdras.2017.33.1.1
- Author:
Young Gun KIM
1
;
Jung Hee BAE
;
Seong Taek KIM
Author Information
1. Department of Prosthodontics, School of Dentistry, Chosun University, Gwangju, Republic of Korea. lkj1998@chosun.ac.kr
- Publication Type:Review
- Keywords:
botulinum toxin;
pain;
migraine;
chronic headache
- MeSH:
Botulinum Toxins*;
Dystonia;
Forehead;
Glutamic Acid;
Headache Disorders;
Humans;
Migraine Disorders*;
Motor Neurons;
Muscle Spasticity;
Neurogenic Inflammation;
Neurotransmitter Agents;
Paralysis;
Substance P;
Surgery, Plastic;
Temporal Lobe*;
Temporomandibular Joint Disorders
- From:Journal of Dental Rehabilitation and Applied Science
2017;33(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Botulinum toxin (BoNT) injections have been used not only in the field of cosmetic surgery such as forehead and eye wrinkle treatment but also in the treatment of chronic migraine, dystonia, spasticity, temporomandibular disorders (TMD). BoNT injections are the only approved therapies to date for prophylactic treatment of chronic migraine patients. Unlike the previously known paralysis of motor neurons, the mechanism of action for migraine is to block the release of non-cholinergic neurotransmitters such as substance P, CGRP, and glutamate, which are associated with peripheral sensitization and neurogenic inflammation in the sensory nerve, it is hypothesized that the signal is blocked. This review focuses on the analgesic effects of BoNT and suggests the direction for the development of injection methods for chronic migraine patients.
