Effects of host modulation by nonsteroidal anti-inflammatory drugs on periodontal disease: a systematic review and meta-analysis.
10.14368/jdras.2017.33.1.7
- Author:
Dae Young KANG
1
;
In Woo CHO
;
Hyun Seung SHIN
;
Hyeong Sik AHN
;
Hyun Jung KIM
;
Jung Chul PARK
Author Information
1. Department of Periodontology, College of Dentistry, Dankook University, Cheonan, Republic of Korea. jcp@dent.dku.edu
- Publication Type:Meta-Analysis ; Original Article
- Keywords:
anti-inflammatory agents;
non-steroidal;
drug therapy;
meta-analysis;
periodontal diseases;
prostaglandins
- MeSH:
Anti-Inflammatory Agents;
Arachidonic Acid;
Drug Therapy;
Humans;
Periodontal Diseases*;
Prostaglandins
- From:Journal of Dental Rehabilitation and Applied Science
2017;33(1):7-18
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Nonsteroidal anti-inflammatory drugs that prohibit biosynthesis of arachidonic acid metabolites have been considered potent host modulation agents. The aim of this review was to determine the effect of nonsteroidal anti-inflammatory drugs adjunctive with nonsurgical periodontal treatment in patients with periodontal disease. MATERIALS AND METHODS: Three electronic databases were searched to identify relevant studies. The methodological quality and mean differences of the change in clinical attachment level and probing depth were analyzed according to Cochrane review methods. RESULTS: Twelve studies were included in the methodological assessment and nine studies were suitable for inclusion in the meta-analysis. The mean difference in the clinical attachment level gain did not differ significantly between the nonsteroidal anti-inflammatory drugs and control groups at any observation time. The highest mean difference in clinical attachment level gain was 0.30 mm at 4 weeks (95% confidence interval = -0.37 to 0.97). There was a significant mean difference in the probing depth reduction, of 0.34 mm (95% confidence interval = 0.29 to 0.40) at 6 weeks. CONCLUSION: Therefore, nonsteroidal anti-inflammatory drugs have additional therapeutic effect when administrated with nonsurgical periodontal treatment.
