Altered Regulation of Renal Aquaporins and Sodium Transporters in Experimental Chronic Renal Failure.
- Author:
Tae Hwan KWON
1
Author Information
1. Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Korea. thkwon@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Kidney Failure;
Chronic;
Aqauporins;
Membrane transport proteins
- MeSH:
Aquaporins*;
Glomerular Filtration Rate;
Kidney;
Kidney Failure, Chronic*;
Membrane Transport Proteins;
Nephrons;
Renal Insufficiency;
Sodium*
- From:Electrolytes & Blood Pressure
2005;3(2):91-96
- CountryRepublic of Korea
- Language:English
-
Abstract:
Chronic renal failure, which has an increased single nephron glomerular filtration rate in remnant kidney, is known to cause characteristic structural alterations in renal tubule epithelia in association with impaired urinary concentration and deranged urinary sodium excretion. This mini-review will deal with the changes in the renal expression of aquaporins (AQPs) and sodium transporters for elucidating the underlying cellular and molecular mechanisms for the urinary abnormalities of decreased urinary concentration and increased urinary sodium excretion.
