Vitamin D Resistant Rickets
10.4055/jkoa.1978.13.1.67
- Author:
Chang Ju LEE
;
Ik Yeol CHANG
;
Won Chang PARK
- Publication Type:Case Report
- MeSH:
Familial Hypophosphatemic Rickets;
Fractures, Spontaneous;
Humans;
Hypocalcemia;
Lower Extremity;
Physiology;
Public Health;
Rickets;
Sunlight;
Vitamin D;
Vitamins
- From:The Journal of the Korean Orthopaedic Association
1978;13(1):67-73
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The discovery and synthesis of vitamin D and the elucidation of the role of sunlight in the activation of the vitamin D precursors changed the syndromes of rickets from a therapeutic enigma to a socioeconomic and public health problem. Since Albright in 1937 first described vitamin D resistsnt rickets, which did not respond to treatment with the usual dose of vitamin D, it has progressively become a common form of rickets in practice. In addition, as the result of increasing understanding of renal physiology and careful investigation, a spectrum of renal tubular abnormalities have been identified which cause clinical rickets and which in many cases are insensitive to even large doses of vitamin D. We have reported a case of an unusual form of vitamin D resistant rickets which did not easily respond to treatment with high doses of vitamin D and was associated with hypocalcemia in multiple pathologic fractures in the lower extremities of the patient.
