The Effect of Intra-articular Injection of Steroid on Lysozyme Activity in Patient with Rheumatoid Arthritis
10.4055/jkoa.1976.11.1.110
- Author:
Jung Yoon LEE
;
Boo Hwan KIM
- Publication Type:Original Article
- MeSH:
Arthritis, Rheumatoid;
Humans;
Injections, Intra-Articular;
Joints;
Knee Joint;
Muramidase;
Osteoarthritis;
Reference Values
- From:The Journal of the Korean Orthopaedic Association
1976;11(1):110-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The lysozyme activities of knee joint fluid in normal Korean people, patients with rheumatoid arthritis, and patients with degenerative arthritis have been reported by Lee in 1974. This time I have studied the chronologic changes of lysozyme activity of knee joint fluid in patients with rheumatoid arthritis following intra-articular injection of steroid preparation (6-methylprednisolone acetate). The results obtained were as follows. 1. The synovial concentration of lysozyme in patients with rheumatoid arthritis was found to be 10.88 mcg/ml which is higher than normal value of 8.69 mcg/ml. 2. The lysozyme activity of joint fluid obtained 5 days after intra-articular injection of steroid prepatation was variable ranging from 7.40 mcg/ml to 10.0mcg/ml with the average of 8.97 mcg/ml, which corresponded to the relief of clinical manifestations. 3. The lysozyme activity of joint fluid obtained 10 days after intra-articular injection of steroid preparation decreased to 8.36 mcg/ml on average with the range from 7.60 to 9.30 mcg/ml which was in accordance with much relief of clinical manifestations. 4. The lysozyme activity of joint fluid obtained 20 days after intra-articular steroid injection was 9.55 mcg/ml on average with the range from 8.25 to 11.25 mcg/ml which was in accordance with the aggravations of clinical manifestations.
