Significance of p53 as a Prognostic Factor in Non-Small Cell Lung Carcinoma.
- Author:
In Seok JANG
1
;
Sangho RHIE
;
Jung Ho HAN
;
Kwhanmien KIM
;
Jhingook KIM
;
Young Mog SHIM
Author Information
1. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Gyeongsang National University, Hospital, Institute of Health Science, Korea. inseok1@netian.com
- Publication Type:Original Article
- Keywords:
Lung cancer;
Apoptosis
- MeSH:
Adenocarcinoma;
Apoptosis;
Carcinoma, Non-Small-Cell Lung;
Carcinoma, Squamous Cell;
Cell Differentiation;
Classification;
Drug Therapy;
Female;
Follow-Up Studies;
Genes, p53;
Humans;
Lung Neoplasms;
Lung*;
Mortality;
Pneumonectomy;
Prognosis;
Radiotherapy;
Retrospective Studies
- From:The Korean Journal of Thoracic and Cardiovascular Surgery
2004;37(8):672-685
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The treatment results of the advanced lung carcinoma is not satisfactory with the present therapeutic modalities: surgical resection, anti-cancer chemotherapy, and radiotherapy or combination therapy. To predict the prognosis of the non-small-cell lung carcinoma, TNM classification has been was as the basic categorization; however, it has been not satisfactory. It is necessary to consider the causes and the prognosis of the lung carcinoma from another points of view rather the conventional methods. We intended to find out the relationship between the major apoptotic factor, p53 gene and the prognosis of the patient with lung carcinoma. MATERIAL AND METHOD: Three hundreds and fifty-nine patients with lung carcinoma who underwent surgery were analysed. We observed p53 protein accumulated in the cellular nuclei. The p53 protein was detected by immuno-histo-chemical method. We collected information of the patient retrospectively. RESULT: p53 protein densities were observed in 40% in average as a whole. The protein density was 44 percent in man, 25 percent in woman, 49 percent in the squamous cell carcinoma, and 38 percent in the adenocarcinoma. There were significant correlations between the p53 protein density and the mortality in the squamous cell carcinoma (p=0.025), follow-up duration in TNM stage I group (p=0.010), and follow-up duration in the lobectomy patient group (p=0.043), and tumor cell differentiation (p=0.009). p53 protein densities were significantly different between the lobectomy and the pneumonectomy group (p=0.044). CONCLUSION: The authors found that p53 protein had some correlations with the prognosis of the lung cancer partially in some factors. We suggest the p53 protein density could be used as a marker of prognosis in the non-small-cell lung carcinoma.
