Development of Severe Hemolytic Anemia after Treatment with Anti-D Immunoglobulin in a Patient with Immune Thrombocytopenic Purpura.
- Author:
Bo Kyeung JUNG
1
;
Jang Su KIM
;
Seung Gyu YUN
;
Sun Young KO
;
Chi Hyun CHO
;
Chae Seung LIM
Author Information
1. Department of Laboratory Medicine, Guro Hospital, Korea University College of Medicine, Seoul, Korea. malarim@korea.ac.kr
- Publication Type:Case Report
- Keywords:
Anti-D immunoglobulin;
Immune thrombocytopenic purpura;
Hemolytic anemia
- MeSH:
Aged;
Anemia, Hemolytic;
Biopsy;
Bone Marrow;
Epistaxis;
Female;
Hemoglobinuria;
Hemolysis;
Humans;
Hyperbilirubinemia;
Immunoglobulins;
Isoantibodies;
Leg;
Nephritis;
Platelet Count;
Purpura, Schoenlein-Henoch;
Purpura, Thrombocytopenic, Idiopathic;
Thrombocytopenia
- From:Korean Journal of Blood Transfusion
2012;23(1):72-77
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 78-year-old female was admitted due to nasal bleeding and purpuric macules on both legs. The patient underwent renal biopsy, and a diagnosis of Henoch-Schonlein purpura nephritis was made. The patient's platelet count was 1.6x10(10)/L, and, based on results from bone marrow biopsy, the patient was diagnosed with immune thrombocytopenic purpura. Despite treatment with glucocorticoid and IV immunoglobulin, thrombocytopenia continued. The patient's blood group was Rhesus D positive and treatment with IV anti-D immunoglobulin followed. Thereafter, platelet count showed a rapid increase; however, occurrence of hemolytic anemia, hyperbilirubinemia, and hemoglobinuria consistent with intravascular hemolysis was observed.
