Thyroid Abnormality and Dry Eye Syndrome: a Cross-sectional Study from the Republic of Korea
10.3341/jkos.2019.60.8.725
- Author:
Yeseul KIM
1
;
Jin Kwon CHUNG
;
Si Hyung LEE
Author Information
1. Department of Ophthalmology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. sieh12@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
Dry eye syndrome;
Thyroid cancer;
Thyroid disease
- MeSH:
Body Mass Index;
Cross-Sectional Studies;
Dataset;
Dry Eye Syndromes;
Female;
Humans;
Hyperlipidemias;
Hypertension;
Male;
Nutrition Surveys;
Prospective Studies;
Republic of Korea;
Thyroid Diseases;
Thyroid Gland;
Thyroid Neoplasms
- From:Journal of the Korean Ophthalmological Society
2019;60(8):725-730
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To investigate the relationship between thyroid abnormality and dry eye syndrome (DES) in a nationally representative Korean population. METHODS: A population-based prospective cross-sectional study was conducted, using the thyroid abnormality data set of the Korean National Health and Nutrition Examination Survey, 2010 – 2012. A total of 16,966 Korean participants with DES were enrolled in the study. RESULTS: The DES patients were predominantly women, non-smokers and non-drinkers, living in urban regions, with a low income and body mass index (BMI), and with a higher percentage of hypertension, hyperlipidemia, thyroid abnormalities, thyroid diseases, and thyroid cancers. After adjusting for all significant variables, thyroid abnormality (odds ratio [OR], 1.93; 95% confidence interval [CI], 1.43–2.61), thyroid disease (OR, 1.85; 95% CI, 1.37–2.52), and thyroid cancer (OR, 2.45; 95% CI, 1.06–5.67) were significantly associated with DES. There was also a significant association between DES and thyroid abnormalities (OR, 2.02; 95% CI, 1.47–2.76), thyroid diseases (OR, 1.93; 95% CI, 1.41–2.65), and thyroid cancer (OR, 2.62; 95% CI, 1.06–6.62) in the female group, but there was no significant association in the male group. CONCLUSIONS: Thyroid abnormalities, thyroid diseases, and thyroid cancers were associated with DES in a nationally representative Korean population. Close evaluation of thyroid abnormalities is therefore needed when treating female patients.
