Effect of 3% Diquafosol Tetrasodium on Tear Film Stability after Laser-assisted in situ Keratomileusis
10.3341/jkos.2019.60.10.915
- Author:
Chang Hwan KIM
1
;
San SEONG
;
Jong Ku KIM
;
Jae Ho CHOI
;
Chul Myong CHOE
;
Tae Hoon CHOI
;
Sekyung KIM
Author Information
1. Nune Eye Hospital, Seoul, Korea. sekyungkim@naver.com
- Publication Type:Original Article
- Keywords:
Diquafosol;
Dry eyes;
Laser-assisted in-situ keratomileusis;
Tear film stability
- MeSH:
Fluorescein;
Humans;
Hyaluronic Acid;
Keratomileusis, Laser In Situ;
Osmolar Concentration;
Prospective Studies;
Tears
- From:Journal of the Korean Ophthalmological Society
2019;60(10):915-921
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the efficacy of 3% diquafosol tetrasodium (DQ) after laser-assisted in-situ keratomileusis (LASIK). METHODS: This prospective randomized study included 150 eyes in 75 patients who were scheduled for LASIK. The patients in the 3% diquafosol tetrasodium (DQ) group (37 patients, 74 eyes) were instructed to apply one drop of DQ, six times daily post-op, while the patients in the 0.3% sodium hyaluronate (HA) group (38 patients, 76 eyes) were instructed to apply one drop of HA, six times daily post-op. A Schirmer test, tear film break-up time (BUT), corneal and conjunctival fluorescein staining score (FLSS), and ocular surface disease index (OSDI) were evaluated pre-op and at 1, 4, and 12 weeks post-op while the tear osmolarity was evaluated pre-op and at 4 and 12 weeks post-op. RESULTS: There was no significant difference between the two groups regarding Schirmer test results or tear osmolarity and conjunctival FLSS. The BUT was significantly higher in the DQ group at 1 week and 12 weeks post-op. The corneal FLSS was significantly lower in the DQ group at 1 week, 4 weeks and 12 weeks post-op. The OSDI was significantly lower in the DQ group at 1 week post-op. CONCLUSIONS: Use of 3% diquafosol tetrasodium after surgery improved ocular dryness and increased the tear film stability.
