Bilateral Lesions in the Posterior Limb of Internal Capsule Attributed to Combination Therapy of Isoniazid and Rifampin
- Author:
Min Won PARK
1
;
Jinhong ROH
;
Seojun IM
;
Min Ok KIM
;
Young Soo KIM
;
Jongsoo KANG
;
Do Hyung KIM
;
Oh Young KWON
Author Information
- Publication Type:Case Report
- Keywords: Isoniazid; Neurotoxicity syndromes; Internal capsule
- MeSH: Brain; Cerebellar Nuclei; Cerebellum; Dysarthria; Extremities; Female; Hand; Humans; Hypesthesia; Internal Capsule; Isoniazid; Neurotoxicity Syndromes; Rifampin; Thalamus
- From:Journal of the Korean Neurological Association 2018;36(4):354-357
- CountryRepublic of Korea
- Language:Korean
- Abstract: Transient isoniazid-induced brain lesions have rarely been reported. The lesions were in the dentate nucleus of cerebellum and thalamus. Meanwhile, the neurotoxicity of rifampin has not been reported evidently. We observed bilateral lesions in the internal capsule in a young woman after taking a combination of isoniazid and rifampin. She transiently suffered numbness in both hands, dysarthria, and left side motor weakness while taking the medication. Isoniazid may induce structural lesions in various brain areas including the internal capsule.
