Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population.
10.3904/kjim.2015.30.5.719
- Author:
Sook Kyung DO
1
;
Seung Soo YOO
;
Yi Young CHOI
;
Jin Eun CHOI
;
Hyo Sung JEON
;
Won Kee LEE
;
Shin Yup LEE
;
Jaehee LEE
;
Seung Ick CHA
;
Chang Ho KIM
;
Jae Yong PARK
Author Information
1. Department of Biochemistry and Cell Biology, Kyungpook National University School of Medicine, Daegu, Korea. jaeyong@knu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Polymorphisms;
Replication;
Telomere length
- MeSH:
Adult;
Aged;
Asian Continental Ancestry Group/*genetics;
Case-Control Studies;
DNA-Binding Proteins/genetics;
Female;
Genome-Wide Association Study;
Genotype;
Humans;
Kruppel-Like Transcription Factors/genetics;
Male;
Middle Aged;
Phenotype;
*Polymorphism, Single Nucleotide;
Republic of Korea;
Telomerase/genetics;
Telomere/*genetics/metabolism;
*Telomere Homeostasis;
Zinc Fingers
- From:The Korean Journal of Internal Medicine
2015;30(5):719-726
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17 polymorphisms identified in Caucasians on telomere length in a Korean population. METHODS: Ninety-four healthy individuals were enrolled in this study. Relative telomere length of chromosomes from peripheral blood samples was measured using quantitative polymerase chain reaction. RESULTS: Two polymorphisms, rs10936599 of MYNN and rs412658 of ZNF676, were found to be associated w ith telomere length (under dominant model, p = 0.04; under recessive model, p = 0.001). Three polymorphisms, rs2853669, rs7705526, and rs2736108, at the TERT locus were also associated with telomere length (under recessive model, p = 0.01, p = 0.02, and p = 0.01, respectively). The genotypes of the five polymorphisms associated with short telomere length were considered bad genotypes; telomere length was significantly decreased with increasing number of bad genotypes (p= 1.7 x 10(-5)). CONCLUSIONS: We have identified polymorphisms associated with telomere length in a Korean population.
