Cerebral Venous Thrombosis Presenting in Pregnancy with Thrombocytosis and Janus Kinase 2 Valine-to-Phenylalanine Mutation
- Author:
Seung Jae YOON
1
;
Min Hee WOO
;
Darda CHUNG
;
Jinkwon KIM
Author Information
- Publication Type:Case Report
- Keywords: Venous thrombosis; Pregnancy; Janus Kinase 2
- MeSH: Abducens Nerve Diseases; Adult; Brain; Diplopia; Female; Headache; Heparin, Low-Molecular-Weight; Humans; Janus Kinase 2; Magnetic Resonance Imaging; Pregnancy; Thrombocytosis; Venous Thrombosis
- From:Journal of the Korean Neurological Association 2018;36(3):192-195
- CountryRepublic of Korea
- Language:Korean
- Abstract: A 30-year-old woman in her first pregnancy was admitted with headache and horizontal diplopia indicating left abducens nerve palsy. Brain magnetic resonance imaging revealed a cerebral venous thrombosis. She had thrombocytosis in the peripheral blood, and a genetic test for thrombocytosis revealed the presence of the valine-to-phenylalanine (V617F) mutation of the Janus kinase 2 (JAK2) gene. Treatment with low-molecular-weight heparin resolved her symptoms of headache and diplopia. The presence of genetic disorders such as the JAK2-V617F gene mutation should be assessed in patients with cerebral venous thrombosis and coexisting thrombocytosis.
