Metronidazole-Induced Encephalopathy with Thiamine Deficiency
- Author:
Rae Young KIM
1
;
Deok Soo LEE
;
Byeong Cheol GWAG
;
Yoon Kyung LEE
;
Sang Myeong CHEON
;
Jin Heon JEONG
Author Information
- Publication Type:Case Report
- Keywords: Metronidazole; Encephalopathy; Thiamine
- MeSH: Brain Diseases; Corpus Callosum; Female; Humans; Magnetic Resonance Imaging; Mesencephalon; Metronidazole; Middle Aged; Pons; Thiamine Deficiency; Thiamine
- From:Journal of the Korean Neurological Association 2018;36(2):116-118
- CountryRepublic of Korea
- Language:Korean
- Abstract: Metronidazole-induced encephalopathy (MIE) can be caused by excessive dose or prolonged metronidazole administration. The signal abnormalities in the cerebellar dentate nuclei, midbrain, dorsal pons and corpus callosum on magnetic resonance imaging are considered as the characteristic feature of MIE. Although the mechanism of MIE remains to be elucidated, various hypothesis have been proposed including the role of metronidazole as a thiamine antagonist. Here we report a 58-year-old woman with MIE who coincidentally presented with thiamine deficiency.
