An Autopsy Confirmed Case of Semantic Variant Primary Progressive Aphasia with Frontotemporal Lobar Degeneration-TDP type C
- Author:
Na Yeon JUNG
1
;
Myung Jun LEE
;
Jae Hyeok LEE
;
Jin Hong SHIN
;
Young Min LEE
;
Myung Jun SHIN
;
Kyoungjune PAK
;
Chungsu HWANG
;
Jae Woo AHN
;
Suk SUNG
;
Kyung Un CHOI
;
Gi Yeong HUH
;
Eun Joo KIM
Author Information
- Publication Type:Case Report
- Keywords: Semantic dementia; Frontotemporal lobar degeneration; TDP-43 proteinopathies
- MeSH: Aggression; Apathy; Aphasia, Primary Progressive; Atrophy; Autopsy; Brain; Cerebral Cortex; Comprehension; Diagnosis; Eating; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Magnetic Resonance Imaging; Middle Aged; Neurites; Pathology; Pneumonia; Semantics; TDP-43 Proteinopathies; Temporal Lobe
- From:Journal of the Korean Neurological Association 2018;36(1):35-39
- CountryRepublic of Korea
- Language:Korean
- Abstract: A 62-year-old man presented with a one-year history of word finding difficulty, impaired single word comprehension and personality changes including aggression, apathy and eating change. Brain MRIs showed severe atrophy in the left anterior temporal lobe. The clinical syndromic diagnosis was semantic variant primary progressive aphasia. He died at age 70 of pneumonia. At autopsy, transactive response DNA-binding protein (TDP) immunoreactive long dystrophic neurites were predominantly found in the cerebral cortices, which were compatible with frontotemporal lobar degeneration-TDP type C pathology.
