Pharmacotherapy for attention-deficit/hyperactivity disorder
10.5124/jkma.2019.62.1.49
- Author:
Bongseog KIM
1
Author Information
1. Department of Psychiatry, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. kimbs328@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Attention deficit disorder with hyperactivity;
Pharmacotherapy;
Methylphenidate;
Atomoxetine hydrochloride
- MeSH:
Appetite;
Atomoxetine Hydrochloride;
Attention Deficit Disorder with Hyperactivity;
Caregivers;
Compliance;
Drug Therapy;
Friends;
Guanfacine;
Headache;
Humans;
Impulsive Behavior;
Mass Screening;
Methylphenidate;
Neurodevelopmental Disorders;
Norepinephrine;
Prevalence;
Problem Behavior;
Tics
- From:Journal of the Korean Medical Association
2019;62(1):49-55
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder defined by impairing levels of inattention, disorganization, and/or hyperactivity-impulsivity. ADHD often persists into adulthood, with resultant impairments of social, academic and occupational functioning. ADHD is a very common disease during childhood and, the pooled overall prevalence of ADHD was found to be 5.29%. When screening for ADHD, clinicians should try to develop rapport with patients and their caregivers to increase the likelihood that they will follow the diagnostic process and treatment. The current drugs that have received Food and Drug Administration-approval for ADHD include stimulants (methylphenidate and dextroamphetamine) and non-stimulants (atomoxetine, guanfacine, and clonidine). Stimulants improve inattention, hyperactivity, and impulsivity in addition to decreasing disruptive behaviors and promoting academic achievement and the maintenance of appropriate friendships. In order to enhance drug compliance, the use of long-acting stimulants is increasing. Atomoxetine is a selective norepinephrine reuptake blocker, the effects of which may take 2 to 6 weeks to be noticeable. Furthermore, α2 agonists may help to improve behavioral side effects, tics, and sleep problems during stimulant or atomoxetine use. Common side effects of stimulants and atomoxetine include headache, stomachache, and loss of appetite. Routine electorcardiography before medication is not recommended unless there is a specific indication. Methylphenidate and atomoxetine are safe as first line therapies, and their side effects are well tolerated.
