Pathophysiology and new treatment of itch
10.5124/jkma.2018.61.11.670
- Author:
Min Je JUNG
1
;
Yong Won CHOI
;
Bo Young CHUNG
;
Chun Wook PARK
;
Hye One KIM
Author Information
1. Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea. hyeonekim@gmail.com
- Publication Type:Original Article
- Keywords:
Pruritus;
Etiology;
Therapy
- MeSH:
Epidermis;
Histamine;
Histamine Antagonists;
Humans;
Keratinocytes;
Nerve Fibers;
Neurotransmitter Agents;
Pruritus;
Sensation
- From:Journal of the Korean Medical Association
2018;61(11):670-677
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Many of the patients visit the doctors because of itching sensation. Itching is an unpleasant sensation. In the epidermal keratinocytes, various neurotransmitters and receptors are related itching. The itch signal is mainly transmitted through the lateral spinal ganglion-derived nerve fibers extending to the lower epidermis. Many mediators such as histamine are involved in the itching pathway. It can be helpful in the treatment of patients having itching sensation with a lot of new therapies from the basic medication such as antihistamines. Also, many drugs are currently under study.
