Frozen Cytology of Meningeal Malignant Solitary Fibrous Tumor/Hemangiopericytoma
- Author:
Myunghee KANG
1
;
Na Rae KIM
;
Dong Hae CHUNG
;
Gie Taek YIE
Author Information
- Publication Type:Case Report
- Keywords: Solitary fibrous tumors; Hemangiopericytoma; Frozen; Cytology; Central nervous system
- MeSH: Brain; Central Nervous System; Collagen; Diagnosis; Dizziness; Female; Hemangiopericytoma; Humans; Middle Aged; Mitosis; Population Characteristics; Rhabdoid Tumor; Solitary Fibrous Tumors; STAT6 Transcription Factor; Temporal Lobe
- From:Journal of Pathology and Translational Medicine 2019;53(3):192-197
- CountryRepublic of Korea
- Language:English
- Abstract: A 51-year-old woman presented with severe dizziness. The brain magnetic resonance image revealed a 5.5 cm multiloculated mass with a thick rim in the left temporal lobe. Cytological examination of frozen diagnosis of the mass showed hypercellular sheets of round and rhabdoid cells in a hemorrhagic background, and two mitotic figures were observed. Histologically, the excised dura-based mass consisted of predominantly round cells with small foci of rhabdoid tumor cells in a pseudoalveolar pattern in a hemorrhagic background, and the cells showed nuclear positivity for signal transducer and activator of transcription 6 as well as frequent mitosis. The mass was diagnosed as a grade 3 solitary fibrous tumor (SFT)/hemangiopericytoma (HPC). The cytological diagnosis of SFT/HPC is challenging because of the heterogeneous cytological findings, such as histological heterogeneity, and because there are no standardized cytological criteria for malignant SFT/HPC. Cytological findings, such as singly scattered small cells, hypercellularity, rare ropy collagen, and round and rhabdoid cells with pseudoalveolar pattern, may assist in the diagnosis of malignant SFT/HPC.
