Antibiotics Induced Seizures and Encephalopathy
- Author:
Kyoo Ho CHO
1
Author Information
- Publication Type:Review
- Keywords: Anti-infective agents; Delirium; Neurotoxicity syndromes; Seizures
- MeSH: Anti-Bacterial Agents; Anti-Infective Agents; Brain Diseases; Central Nervous System Diseases; Critical Illness; Delirium; Electroencephalography; Epilepsy; Humans; Intensive Care Units; Neurotoxicity Syndromes; Prognosis; Seizures
- From: Journal of Neurocritical Care 2018;11(1):1-6
- CountryRepublic of Korea
- Language:Korean
- Abstract: Drug-induced seizures and delirium are common among patients with critical illnesses, especially those in an intensive care unit. With an increase in the use of potent, broad-spectrum antibiotics, the etiology for encephalopathy remains under-recognized. Antibiotics-induced nonconvulsive seizures should also be considered in patients with unexplained mental status, therefore continuous electroencephalography monitoring is often needed for its detection. Prompt discontinuation, substitution, or dose adjustment of the causative antibiotics might help improve prognosis. Also, antibiotics should be used with caution especially in patients with known epilepsy, central nervous system disorders, critical illnesses, or renal dysfunction.
