Ahmed Valve Implantation Result and TGF-beta and VEGF in the Aqueous Humor of Neovascular Glaucoma Patients.
- Author:
Won Kyung SONG
1
;
Jun Haeng LEE
;
Young Jae HONG
;
Chan Yun KIM
Author Information
1. The Institute of Vision Research, Department of Ophthalmology, Yonsei University College of Medicine, Hospital, Seoul, Korea. kcyeye@yahoo.co.kr
- Publication Type:Original Article
- Keywords:
Ahmed valve;
Neovascular glaucoma;
Transforming growth factor-beta;
Vascular endothelial growth factor
- MeSH:
Aqueous Humor*;
Glaucoma;
Glaucoma, Neovascular*;
Humans;
Intraocular Pressure;
Transforming Growth Factor beta*;
Transforming Growth Factor beta1;
Transforming Growth Factor beta2;
Vascular Endothelial Growth Factor A*
- From:Journal of the Korean Ophthalmological Society
2006;47(4):571-576
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess the relationship of transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF) levels in the aqueous humor of neovascular glaucoma (NVG) patients and the results of Ahmed valve implantation surgery. METHODS: We compared surgical outcomes of NVG patients who underwent Ahmed valve implant surgery from January 2002 through October 2002 at severance hospital with levels of TGF-beta1, TGF-beta2 and VEGF in the aqueous humors of these patients. RESULTS: Nineteen eyes (19 patients) were analyzed in the study. The success of surgery was defined as intraocular pressure maintained as 6-20 mm Hg regardless of additional glaucoma medications taken. Twelve eyes (63%) satisfied successful surgery. TGF-beta1 concentration was 1.51 ng/ml in the success group and 2.31 ng/ml in the failed group (p=0.295). TGF-beta2 concentration was 5.19 ng/ml in the success group and 5.73 ng/ml in the failed group (p=0.367). VEGF concentration was 10.21 ng/ml in the success group and 9.87 ng/ml in the failed group (p=0.516). All showed no statistical difference between the groups. CONCLUSIONS: In our study, no significant relationship between levels of TGF-beta1, TGF-beta2, or VEGF in the aqueous humor and the surgical outcomes of Ahmed valve implantation were found in patients with NVG.
