Pseudobulbar Affect in Parkinsonian Disorders: A Review
- Author:
Mathew HAKIMI
1
;
Carine W MAURER
Author Information
- Publication Type:Review
- Keywords: Pseudobulbar affect; Parkinson's disease; parkinsonism
- MeSH: Abstracting and Indexing as Topic; Amyotrophic Lateral Sclerosis; Crying; Laughter; Multiple Sclerosis; Parkinson Disease; Parkinsonian Disorders; Prevalence; Quality of Life; Symptom Assessment
- From:Journal of Movement Disorders 2019;12(1):14-21
- CountryRepublic of Korea
- Language:English
- Abstract: Pseudobulbar affect (PBA) is a neurological symptom of inappropriate and uncontrollable laughter or crying that occurs secondary to a variety of neurological conditions, including parkinsonian disorders. PBA is a socially and emotionally debilitating symptom that has been estimated to affect 3.6% to 42.5% of the population with Parkinson’s disease. While indexing measures and treatment options for PBA have been extensively studied in neurological conditions such as amyotrophic lateral sclerosis and multiple sclerosis, there has been considerably less attention given in the literature to PBA in parkinsonian disorders. The purpose of this review is to discuss the pathophysiology of PBA, its prevalence and impact on quality of life in parkinsonian disorders, and the treatment options currently available. Areas requiring further study, including the development of standardized, cross-culturally validated methods of symptom assessment, and evidence-based studies exploring the efficacy of current treatment options in parkinsonian disorders, are also highlighted.
