Prospective Characterization of Cognitive Function in Typical and ‘Brainstem Predominant'Progressive Supranuclear Palsy Phenotypes

Author: Young Eun C LEE ¹ ; David R WILLIAMS ; Jacqueline F I ANDERSON
Author Information

1. Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia. jfande@unimelb.edu.au
Publication Type:Original Article
Keywords: Progressive supranuclear palsy; phenotypes; cognition; neuropsychology
MeSH: Cognition; Executive Function; Freezing; Gait; Humans; Neuropsychological Tests; Neuropsychology; Paralysis; Phenotype; Prospective Studies; Supranuclear Palsy, Progressive
From:Journal of Movement Disorders 2018;11(2):72-77
CountryRepublic of Korea
Language:English
Abstract: OBJECTIVE: Clinicopathological studies over the last decade have broadened the clinical spectrum of progressive supranuclear palsy (PSP) to include several distinct clinical syndromes. We examined the cognitive profiles of patients with PSP-Richardson's syndrome (PSP-RS) and two atypical ‘brainstem predominant' PSP phenotypes (PSP-parkinsonism, PSP-P; and PSP-pure akinesia with gait freezing, PSP-PAGF) using a comprehensive neuropsychological battery. METHODS: Fourteen patients diagnosed as PSP-RS, three patients with PSP-P and four patients with PSP-PAGF were assessed using a comprehensive battery of neuropsychological tests.