Early Onset Polymorphic Post-transplant Lymphoproliferative Disease Mimicking a Solitary Necrotizing Abscess in a Graft Liver
- Author:
Pil Soo SUNG
1
;
Jaejun LEE
;
Joon LEE
;
Hee Chul NAM
;
Si Hyun BAE
;
Seung Kew YOON
Author Information
- Publication Type:Case Report
- Keywords: Post-transplantation lymphoproliferative disease; Epstein-Barr virus; ¹⁸F-fluorodeoxyglucose positron emission tomography
- MeSH: Abscess; Biopsy; Carcinoma, Hepatocellular; Hepacivirus; Herpesvirus 4, Human; Liver Transplantation; Liver; Magnetic Resonance Imaging; Necrosis; Organ Transplantation; Positron-Emission Tomography; Prognosis; Seroconversion; Transplant Recipients; Transplants
- From:Journal of Liver Cancer 2019;19(2):165-170
- CountryRepublic of Korea
- Language:English
- Abstract: Although post-transplantation lymphoproliferative disease (PTLD) after liver transplantation is very rare, its prognosis is worse than that of PTLD following other types of solid organ transplantation. Here, we report a rare case of early onset polymorphic PTLD in a graft liver occurring five months after deceased-donor liver transplantation due to hepatocellular carcinoma and hepatitis C virus infection. Initially, findings from contrast-enhanced magnetic resonance imaging mistakenly suspected the lesion was a necrotizing abscess with central necrosis. However, ¹⁸F-fluorodeoxyglucose positron emission tomography and biopsy findings confirmed an Epstein-Barr virus (EBV)-associated, B cell type polymorphic PTLD with central necrosis. Our case suggests regular monitoring of EBV serologic status for liver transplant recipients who were initially in an EBV seronegative state. Although early-onset PTLD is very rare after liver transplantation, PTLD should be suspected when recipients show the seroconversion for EBV proteins and the development of new tumors with various clinical presentations.
