Hepatic Failure Due to Hepatitis E Virus Infection in a Patient with Necrotic Hepatocellular Carcinoma
- Author:
Ji Hye KIM
1
;
Young Seok DOH
;
Ji Woong JANG
;
Min Seok KANG
;
Nak Min KIM
;
Sae Hee KIM
;
Il Hyun BAEK
;
Sung Hee JUNG
Author Information
- Publication Type:Case Report
- Keywords: Hepatocellular carcinoma; Regression; Hepatitis E virus; Liver failure
- MeSH: Alcohol Drinking; Alcoholics; Ascites; Carcinoma, Hepatocellular; Hepatitis E virus; Hepatitis E; Hepatitis; Hepatorenal Syndrome; Herbal Medicine; Hernia, Umbilical; Humans; Immunoglobulin M; Jaundice; Liver; Liver Cirrhosis; Liver Failure; Meat; Middle Aged; Ostreidae; Skin; Transcutaneous Electric Nerve Stimulation
- From:Journal of Liver Cancer 2019;19(1):55-58
- CountryRepublic of Korea
- Language:English
- Abstract: In patients with hepatocellular carcinoma (HCC) or liver cirrhosis (LC) accompanied by hepatitis E virus (HEV) infection, hepatic failure often leads to debility. Here, we report about a 63-year-old man with alcoholic LC who was referred to our hospital with jaundice and abdominal distension 10 days earlier. Abdominal computed tomography showed necrotic HCC accompanied by left lobe shrinkage without tumor progression. Laboratory and imaging findings revealed no acute infection focus. The patient reported no herbal medicine or alcohol consumption, and there was no evidence of acute viral hepatitis. One month later, HEV immunoglobulin M positivity was confirmed, and deterioration of liver function due to HEV infection was suspected. The patient often ate raw oysters and sashimi, as well as boar meat, which is a well-known risk food for HEV infection. His umbilical hernia deteriorated due to tense ascites and infection by skin abrasion. The patient progressed to hepatorenal syndrome and eventually died. Liver function preservation is important when treating HCC patients. Therefore, clinicians should pay more attention to the prevention of HEV and others causes of direct liver injury.
