Liver Transplantation after Successful Downstaging with Hepatic Arterial Infusion Chemotherapy in a Patient with Hepatocellular Carcinoma with Portal Vein Tumor Thrombus
- Author:
Hee Chul NAM
1
;
Pil Soo SUNG
;
Ho Jong CHUN
;
Dong Goo KIM
;
Jeong Won JANG
;
Jong Young CHOI
;
Seung Kew YOON
Author Information
- Publication Type:Case Report
- Keywords: Hepatocellular carcinoma; Venous thrombosis
- MeSH: Carcinoma, Hepatocellular; Drug Therapy; Humans; Liver Transplantation; Liver; Portal Vein; Prognosis; Thrombosis; Venous Thrombosis
- From:Journal of Liver Cancer 2019;19(1):64-68
- CountryRepublic of Korea
- Language:English
- Abstract: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. The majority of patients with HCC are diagnosed at advanced disease stages with vascular invasion, where curative approaches are often not feasible. Currently, sorafenib is the only available standard therapy for HCC with portal vein tumor thrombosis (PVTT). However, in many cases, sorafenib therapy fails to achieve satisfactory results in clinical practice. We present a case of advanced HCC with PVTT that was treated with hepatic arterial infusion chemotherapy (HAIC) followed by liver transplantation. Three cycles of HAIC treatment resulted in necrotic changes in most of the tumors, and PVTT was reduced to an extent at which liver transplantation was possible. Further studies are required to determine the treatment strategies for advanced HCC with PVTT that can improve prognosis.
