Sorafenib Treatment in Advanced Hepatocellular Carcinoma with Tumor Thrombus Nearly Occupying the Entire Right Atrium
- Author:
Young Mo KANG
1
;
Soo Hyung RYU
;
Bo Kyung LEE
;
Kyoung Ho KO
;
Tae Young PARK
;
Jeong Seop MOON
;
Seon Hwa CHO
Author Information
- Publication Type:Case Report
- Keywords: Sorafenib; Thrombosis; Hepatocellular carcinoma; Right atrium
- MeSH: Carcinoma, Hepatocellular; Heart Atria; Hepatic Veins; Humans; Liver; Palliative Care; Thrombosis; Vena Cava, Inferior
- From:Journal of Liver Cancer 2018;18(2):142-145
- CountryRepublic of Korea
- Language:English
- Abstract: Advanced hepatocellular carcinoma (HCC) with tumor thrombus extending through the hepatic veins, inferior vena cava, and right atrium (RA) is very rare. However, whether active treatments such as radiation, transcatheter arterial chemoembolization, and sorafenib in advanced HCC with RA involvement prolong survival is uncertain. We present a rare case of advanced HCC with tumor thrombus nearly occupying the entire RA that was treated with sorafenib. The patient received 400 mg sorafenib twice daily. However, her liver enzyme levels continued to increase and abdominal computed tomography showed an increase in the tumor size in the liver and RA. In the present case, active treatment with sorafenib was ineffective; thus, palliative care may be more beneficial in advanced HCC with extensive RA involvement.
