Translational Application of Single-cell Transcriptomic Analysis in Hepatocellular Carcinoma

Author: Seung Kew YOON ¹
Author Information

1. The Catholic University Liver Research Center & WHO Collaborating Center of Viral Hepatitis, College of Medicine, The Catholic University of Korea, Seoul, Korea. yoonsk@catholic.ac.kr
Publication Type:Review
Keywords: Sequencing; Hepatocellular carcinoma; Transcriptome; RNA sequencing; Circulating tumor cells
MeSH: Biological Processes; Carcinoma, Hepatocellular; Gene Expression Profiling; Genomics; Neoplastic Cells, Circulating; Neoplastic Stem Cells; Prognosis; Sequence Analysis, RNA; Transcriptome
From:Journal of Liver Cancer 2018;18(1):1-8
CountryRepublic of Korea
Language:English
Abstract: The emergence of single-cell technology in recent years has made remarkable progress for understanding of biological process in various diseases including cancers. In particular of cancer, single-cell transcriptome analysis provides a powerful tool for comprehensive characterization of cancer cell subpopulations within a heterogeneous bulk populations. Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer and its molecular mechanism is extremely complex associated with a poor prognosis. To date, the molecular mechanisms of hepatocarcinogenesis remain unclear. Here, I review current status of single-cell transcriptome analysis for HCC, focusing on their application for cancer genomics, circulating tumor cells, cancer stem cells and tumor infiltrating cells in HCC.