Effects of Obesity and Family History of Diabetes on the Association of CETP rs6499861 with HDL-C Level in Korean Populations
10.12997/jla.2019.8.2.252
- Author:
Jae Woong SULL
1
;
Soriul KIM
;
Sun Ha JEE
Author Information
1. Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam, Korea.
- Publication Type:Original Article
- Keywords:
Cholesterol ester transfer proteins;
HDL cholesterol;
Physical activity;
Genetic polymorphisms
- MeSH:
Alleles;
Body Mass Index;
Cholesterol;
Cholesterol Ester Transfer Proteins;
Cholesterol, HDL;
Female;
Genotype;
Humans;
Korea;
Lipoproteins;
Male;
Motor Activity;
Obesity;
Polymorphism, Genetic;
Polymorphism, Single Nucleotide
- From:Journal of Lipid and Atherosclerosis
2019;8(2):252-257
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: The aim of this study was to examine the associations of cholesterol ester transfer protein (CETP) rs6499861 and rs12708980 with high-density lipoprotein cholesterol (HDL-C) considering obesity and family history of diabetes (FHD) in Korean men and women. METHODS: We analyzed the association of CETP single nucleotide polymorphisms (SNPs) with HDL-C among individuals selected from a hospital (n=4 294) and the Bundang-gu area in Korea (n=2 304). RESULTS: We found that the CETP SNP rs6499861 was associated with a lower HDL-C level (effect per allele: −2.044 mg/dL, p<0.0001). Individuals with a rs6499861 CG/GG genotype had a 1.45-fold higher risk of an abnormal level of HDL-C (<40 mg/dL) than those with a CC genotype. This genotype-HDL-C association was stronger in women (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.39–2.85) compared with men (OR, 1.33; 95% CI, 1.10–1.61) and in women with a FHD (OR, 4.82; 95% CI, 1.86–12.5; p=0.0012) compared with women without a family history. Relative to individuals with a CC genotype and body mass index (BMI) <25.69 kg/m², individuals with a CG/GG genotype and BMI ≥25.69 kg/m² had an OR (95% CI) of 2.61 (1.97–3.47). CONCLUSIONS: These findings indicate that CETP variants are linked to HDL-C level in Koreans and that this link is stronger in obese men and in women who have a FHD.
