Serum Insulin-like Growth Factor-1(IGF-1) and Insulin-like Growth Factor Binding Proteins in Hyperthyroidism and Hypothyroidism
- Author:
Hyun Mo SONG
;
Sang Seok PARK
;
Tae Seon PARK
;
Hong Sun BAEK
;
Dae Yeol LEE
- Publication Type:Original Article
- Keywords:
IGF-I;
IGFBP;
Hypothyroidism
- MeSH:
Equidae;
Healthy Volunteers;
Humans;
Hyperthyroidism;
Hypothyroidism;
Insulin-Like Growth Factor Binding Protein 1;
Insulin-Like Growth Factor Binding Protein 2;
Insulin-Like Growth Factor Binding Protein 3;
Insulin-Like Growth Factor Binding Proteins;
Insulin-Like Growth Factor I;
Radioimmunoassay;
Thyroid Hormones
- From:Journal of Korean Society of Endocrinology
1996;11(1):52-60
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Backgrounds: Thyroid hormones play a fundamental role in the initiation and maintenance of somatic growth in mammalian species, and the insulin-like growth factors(IGFs) occupy a position of central importance in the growth of all tissues. To evaluate the changes in serum insulin-like growth factor-I(IGF-I) and insulin-like growth factor binding proteins in hyperthyroid and hypothyroid patients, sera was obtained from 19 hyperthyroid patients, 9 hypothyroid patients, and 10 healthy volunteers. Methods: IGF-I concentration was determined by radioimmunoassay, and changes in IGFBPs were assesed by Western Ligand Blotting. To evaluate the binding pattern of IGF-I & IGFBPs, autoradiographs were obtained. Results & Conclusion: IGF-I levels were increased significantly in hyperthyroid patients(mean ±SE, 267.88±9.80 ng/ml, p<0.05) and decreased significantly in hypothyroid patients(154.81±1.43 ng/ml, p<0.01) compaired to healthy control group(209.45±.60 ng/ml). Autoradiograph of serum IGFBPs from patients with hyperthyroidism and hypothyroidism did not show any change in the intensity of IGFBP-3 bands(40-45 KD) and IGFBP-1 bands, but in hyperthyroid patients, it showed increased intensity of IGFBP-2 band compared to healthy control group and hypothyroid patients.
