Estrogen Replacement Therapy Continuously Combined with Progesterone; Effect on Bone Mineral Density and Lipid Metabolism
- Author:
Keun Yong PARK
- Publication Type:Original Article
- Keywords:
Progesterone;
Bone mineral density
- MeSH:
Bone Density;
Calcium;
Cholesterol;
Estrogen Replacement Therapy;
Estrogens;
Female;
Hormone Replacement Therapy;
Humans;
Lipid Metabolism;
Progesterone
- From:Journal of Korean Society of Endocrinology
1995;10(4):411-417
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A study in 51 healthy postmenopausal women was performed to assess the effect of estrogen replacement therapy continuously combined with progesterone for 6 months on bone mineral density and lipid metabolism.Seventeen hysterectomized women were treated with conjugated estrogen(0.625mg/D), 33 nonhysterectomized women with conjugated estrogen(0.625mg/D) and medroxyprogesterone(2.5mg/D), and 1500mg/day calcium supplementation was given to all patients.After 6 month-treatment, serum total cholesterol and LDL-cholesterol levels were reduced significantly (p<0.01) between the two groups. But lumber BMD and other lipid profiles were not changed significantly between the two groups. Our data suggest that continuously applied progesterone in combined hormone replacement therapy dose not annihilate the beneficial effects on bone mineral density and lipid metabolism induced by estrogen.
